PLATELET THROMBOSIS IN HUMAN HEMOSTASIS
نویسندگان
چکیده
منابع مشابه
Platelet Function in Thrombosis and Hemostasis.
Platelets represent the main effectors in the formation of the initial hemostatic plug through an elaborate response to vascular injury, and furthermore, platelets play an essential role in secondary hemostasis.1 However, platelets are also important contributors to pathological thrombus formation and vessel occlusion when activated inappropriately. Moreover, platelets contribute to processes b...
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an inositol ring. Diphosphoinositol pentakisphosphate (IP7), the most abundant inositol pyrophosphate, is synthesized on phosphorylation of inositol hexakisphosphate (IP6) by IP6 kinases, of which there are 3 mammalian isoforms (IP6K1/2/3) and a single yeast isoform. Yeast lacking IP6 kinase are devoid of polyP, suggesting a role for IP6 kinase in maintaining polyP levels. We theorized that the...
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A close homologue to protein disulfide isomerase (PDI) called ERp57 forms disulfide bonds in glycoproteins in the endoplasmic reticulum and is expressed on the platelet surface. We generated 2 rabbit Abs to ERp57. One Ab strongly inhibited ERp57 in a functional assay and strongly inhibited platelet aggregation. There was minimal cross-reactivity of this Ab with PDI by Western blot or in the fun...
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1Chair of Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG–Research Center for Experimental Biomedicine, Würzburg, Germany; 2Molecular Cell Biology Unit, VIB Department for Molecular Biomedical Research, Ghent University, Ghent, Belgium; 3Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany; 4Biocenter and 5Department of Neurology, University of W...
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ژورنال
عنوان ژورنال: Blood
سال: 1949
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v4.5.631.631